Highlighted Publications
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The Interplay between Mutagenesis and Extrachromosomal DNA Shapes Urothelial Cancer Evolution (under revision in Nature)
Contributors: Nguyen DD, Hooper WF, Chu TR, Geiger H, Shelton JM, Shah M, Goldstein ZR, Winterkorn L, Sigouros M, Manohar J, Moyer J, Wilkes D, Singh RR, Liu W, Sboner A, Taggawa ST, Nanus DM, Nauseef JT, Sternberg CN, Molina AM, Scherr D, Inghirami G, Mosquera JM, Elemento O, Robine N, Faltas BM.
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The evolution of genomic, transcriptomic, and single-cell protein markers of metastatic upper tract urothelial carcinoma
Contributors:Ohara K, Figueiredo Rendeiro A, Bhinder B, Eng KW, Ravichandran H, Nguyen D, Pisapia D, Vosoughi A, Fernandez E, Shohdy KS, Manohar J, Beg S, Wilkes D, Robinson BD, Khani F, Bareja R, Tagawa ST, Ouseph MM, Sboner A, Elemento O, Faltas BM*, Mosquera JM*. (*authors jointly directed this work, co-corresponding authors). The evolution of genomic, transcriptomic, and single-cell protein markers of metastatic upper tract urothelial carcinoma. Nature Communications. 2023 (Accepted, in press)
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Combinatorial genetic strategy accelerates the discovery of cancer genotype-phenotype associations
Contributors: Li S, Wong A, Sun H, Bhatia V, Javier G, Jana S, Montgomery RB, Wright JL, Lam HM, Hsieh AC, Faltas BM, Haffner MC, Lee JK
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Circulating and urinary tumour DNA in urothelial carcinoma - upper tract, lower tract and metastatic disease (2024)
Contributors: Rose KM, Huelster HL, Meeks JJ, Faltas BM, Sonpavde GP, Lerner SP, Ross JS, Spiess PE, Grass GD, Jain RK, Kamat AM, Vosoughi A, Wang L, Wang X, Li R.
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The Cytidine Deaminase APOBEC3G Contributes to Cancer Mutagenesis and Clonal Evolution in Bladder Cancer (2023)
Contirbutors: Liu W, Newhall KP, Khani F, Barlow LM, Nguyen D, Gu L, Eng K, Bhinder B, Uppal M, Récapet C, Sboner A, Ross SR, Elemento O, Chelico L, Faltas BM. This paper was featured on the cover of the February 15, 2023, issue of Cancer Research and accompanied by an editorial highlighting its importance to the field (Caswell and Swanton, Cancer Research, 2023).
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Tumor-Infiltrating Myeloid Cells Confer De Novo Resistance to PD-L1 Blockade through EMT–Stromal and Tgfβ-Dependent Mechanisms (2022)
Contributors: Yu H, Sfakianos JP, Wang L, Hu Y, Daza J, Galsky MD, Sandhu HS, Elemento O, Faltas BM, Farkas AM, Bhardwaj N, Zhu J, Mulholland DJ.
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Serial ctDNA analysis predicts clinical progression in patients with advanced urothelial carcinoma (2022)
Contributors: Shohdy KS, Villamar DM, Cao Y, Trieu J, Price KS, Nagy R, Tagawa ST, Molina AM, Sternberg CN, Nanus DM, Mosquera JM, Elemento O, Sonpavde GP, Grivas P, Vogelzang NJ, Faltas BM.
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Functional comparison of exome capture-based methods for transcriptomic profiling of formalin-fixed paraffin-embedded tumors (2021)
Contributors: Shohdy KS, Bareja R, Sigouros M, Wilkes DC, Dorsaint P, Manohar J, Bockelman D, Xiang JZ, Kim R, Ohara K, Eng K, Mosquera JM, Elemento O, Sboner A, Alonso A, Faltas BM.
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Genomic heterogeneity in bladder cancer: challenges and possible solutions to improve outcomes (2020)
Contributors: Meeks JJ, Al-Ahmadie H, Faltas BM, Taylor JA 3rd, Flaig TW, DeGraff DJ, Christensen E, Woolbright BL, McConkey DJ, Dyrskjøt L.
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Epithelial plasticity can generate multi-lineage phenotypes in human and murine bladder cancers (2020)
Contributors: Sfakianos JP, Daza J, Hu Y, Anastos H, Bryant G, Bareja R, Badani KK, Galsky MD, Elemento O, Faltas BM, Mulholland DJ.
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Common germ line-somatic variants interactions in advanced urothelial cancer (2020)
Contributors: Vosoughi A, Zhang T, Shohdy KS, Vlachostergios PJ, Wilkes DC, Bhinder B, Tagawa ST, Nanus DM, Molina AM, Beltran H, Sternberg CN, Motanagh S, Robinson BD, Xiang J, Fan X, Chung WK, Rubin MA, Elemento O, Sboner A, Mosquera JM, Faltas BM.
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Upper tract urothelial carcinoma has a luminal-papillary T-cell depleted contexture and activated FGFR3 signaling (2019)
Robinson BD, Vlachostergios PJ, Bhinder B, Liu W, Li K, Moss TJ, Bareja R, Park K, Tavassoli P, Cyrta J, Tagawa ST, Nanus DM, Beltran H, Molina AM, Khani F, Miguel Mosquera J, Xylinas E, Shariat SF, Scherr DS, Rubin MA, Lerner SP, Matin SF, Elemento O, Faltas BM.
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Treatment resistance in urothelial carcinoma: an evolutionary perspective (2018)
Vlachostergios PJ, Faltas BM
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Personalized In Vitro and In Vivo Cancer Models to Guide Precision Medicine (2017)
Contributors: Pauli C, Hopkins BD, Prandi D, Shaw R, Fedrizzi T, Sboner A, Sailer V, Augello M, Puca L, Rosati R, McNary TJ, Churakova Y, Cheung C, Triscott J, Pisapia D, Rao R, Mosquera JM, Robinson B, Faltas BM, Emerling BE, Gadi VK, Bernard B, Elemento O, Beltran H, Demichelis F, Kemp CJ, Grandori C, Cantley LC, Rubin MA.
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Clonal Evolution of chemotherapy-resistant urothelial carcinoma (2016)
Contributors: Faltas BM, Prandi D, Tagawa ST, Molina AM, Nanus DM, Sternberg C, Rosenberg J, Mosquera JM, Robinson B, Elemento O, Sboner A
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Cancer is an ancient disease: the case for better palaeoepidemiological and molecular studies (2011)
Contributors: Faltas BM
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