Submitted by bmf9003 on April 18, 2023 - 10:33pm
| Title | Tumor-Infiltrating Myeloid Cells Confer De Novo Resistance to PD-L1 Blockade through EMT-Stromal and Tgfβ-Dependent Mechanisms. |
| Publication Type | Journal Article |
| Year of Publication | 2022 |
| Authors | Yu H, Sfakianos JP, Wang L, Hu Y, Daza J, Galsky MD, Sandhu HS, Elemento O, Faltas BM, Farkas AM, Bhardwaj N, Zhu J, Mulholland DJ |
| Journal | Mol Cancer Ther |
| Volume | 21 |
| Issue | 11 |
| Pagination | 1729-1741 |
| Date Published | 2022 Nov 03 |
| ISSN | 1538-8514 |
| Keywords | B7-H1 Antigen, Humans, Lymphocytes, Tumor-Infiltrating, Myeloid Cells, Signal Transduction, Transforming Growth Factor beta, Tumor Microenvironment, Urinary Bladder Neoplasms |
| Abstract | Most patients with bladder cancer do not respond to ICB targeting of the PD-L1 signaling axis. Our modeling applied a de novo resistance signature to show that tumor-infiltrating myeloid cells promote poor treatment response in a TGFβ-dependent mechanism. |
| DOI | 10.1158/1535-7163.MCT-22-0130 |
| Alternate Journal | Mol Cancer Ther |
| PubMed ID | 36129800 |
| PubMed Central ID | PMC9706595 |
| Grant List | R01 CA197910 / CA / NCI NIH HHS / United States R01 CA201189 / CA / NCI NIH HHS / United States T32 AI007605 / AI / NIAID NIH HHS / United States T32 AI007647 / AI / NIAID NIH HHS / United States |